Effect of Traditional Drug Therapy and its Combination with Soderm®-Forte and New Injectable Form of Rexod® on the Antioxidant-prooxidant Red Blood Cell System in Rats with Experimental Periodontitis

Background. The development of periodontitis is strongly linked with both periodontopathogenic microflora and antioxidant-proxidant system disorders, which determines the need for combined use antimicrobial antioxidant agents. Objectives. A comparative evaluation antioxidant-prooxidant red blood cells in rats experimental against background traditional drug therapy its combination Soderm®-Forte new injectable form Rexod®. Methods. authors conducted a study effect (TDT) gel containing silver nanoparticles, recombinant human superoxide dismutase (Rexod®) (NIF) Rexod® on condition (EP). experiments were performed Wistar male 210–230 g. EP was induced by ligature method. randomly divided into 5 comparable groups 12 animals: group 1 — intact periodontium; 2 EP; 3 EP, where TDT used, including oral irrigation chlorhexedine (0.05% solution) application Septo-Pack dento-gingival dressing; 4 (applied periodontal pockets lower incisors); NIF Rexod®, injected intraperitoneally at dose 8000 U/kg. Treatment (groups 3–5) carried out days. observation period all animals lasted 42 biochemical tests index used to assess system. Statistical analysis obtained results parametric non-parametric methods Microsoft Excel (Microsoft, USA), Analysis package AtteStat, as well Statistica 8.0 (StatSoft, USA) software. Results. developed caused moderate positive correction indicators Antioxidant protection (APS). enrichment especially enhance APS potential more significant dynamics balance compared TDT. Conclusion. has most corrective comparison complex separately.